孕期複合維生素支持母體與胎兒健康。
患有神經管缺陷或其他對葉酸敏感的先天性異常的低風險女性,以及低風險男性伴侶,在受孕前至少 2 至 3 個月、整個懷孕期間、產後 4 至 6 周或母乳餵養期間,需要每天食用富含葉酸的食物和含有 0.4 毫克葉酸的口服複合維生素補充劑。
Wilson RD; Genetics Committee; Wilson RD, Audibert F, Brock JA, Carroll J, Cartier L, Gagnon A, Johnson JA, Langlois S, Murphy-Kaulbeck L, Okun N, Pastuck M; Special Contributors; Deb-Rinker P, Dodds L, Leon JA, Lowel HL, Luo W, MacFarlane A, McMillan R, Moore A, Mundle W, O'Connor D, Ray J, Van den Hof M. Pre-conception Folic Acid and Multivitamin Supplementation for the Primary and Secondary Prevention of Neural Tube Defects and Other Folic Acid-Sensitive Congenital Anomalies. J Obstet Gynaecol Can. 2015 Jun;37(6):534-52. English, French. doi: 10.1016/s1701-2163(15)30230-9. PMID: 26334606.
孕婦在產前攝入含葉酸的多種維生素與好幾種先天性異常的風險降低有關,不僅僅只有神經管缺陷。
Ingrid Goh Y, Bollano E, Einarson TR, Koren G. Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J Obstet Gynaecol Can. 2006 Aug;28(8):680-689. doi: 10.1016/S1701-2163(16)32227-7. PMID: 17022907.
我們發現母親補充葉酸或複合維生素片與兒童患自閉症譜系障礙(ASD)的風險總體呈負相關;在丹麥隊列研究中,母親複合維生素的攝入與較低的多動障礙和 ADHD 藥物風險相關。
Li M, Francis E, Hinkle SN, Ajjarapu AS, Zhang C. Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis. Nutrients. 2019 Jul 17;11(7):1628. doi: 10.3390/nu11071628. PMID: 31319515; PMCID: PMC6682900.

